這兩個詞語意思相同，均表示：無論如何、不管怎樣（接副詞或形容詞）、然而、可是。兩者基本可以通用，但是however的內涵更多，用法更靈活，nevertheless使用使用范圍較窄。

however例句：

1、He can answer the question however hard it is.

不管問題有多難他都能回答。

2、However did you get here?

你是怎么到這里來的?

3、He hasn't arrived. He may, however, come later.

他還未到，不過，他可能過一會兒來。

4、"I'd like to go with you; however, my hands are full."

"我很想和你一塊兒去,可是我忙不過來。"

nevertheless例句：

1、She was very tired, nevertheless she kept on working.

她雖然很疲倦，可仍在繼續工作。

2、He's stupid, but I like him nevertheless.

他是很笨，然而我喜歡他。